Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43.

@article{Salameh2010OpposingAS,
  title={Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43.},
  author={Aida Salameh and Sebastian Karl and Hjalmar Djilali and Stefan Dhein and Jan Janousek and Ingo Daehnert},
  journal={Pharmacological research},
  year={2010},
  volume={62 6},
  pages={506-13}
}
In the heart the most prominent cardiac gap junction protein is connexin43 (Cx43). Increased Cx43 expression has been identified in cardiac hypertrophy and may contribute to arrhythmias. Besides acute effects on gap junction channel function, chronic regulation of Cx43 expression can affect intercellular communication. Since both cyclic mechanical stretch (CMS) and catecholamines play an important role in cardiac physiology and pathophysiology, we wanted to elucidate whether a prolonged β- or… CONTINUE READING

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