Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.

@article{Robertson1992OpposingAO,
  title={Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.},
  author={Brant E. Robertson and Roland Z. Kozlowski and Piers C. G. Nye},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1992},
  volume={102 3},
  pages={459-62}
}
1. We show that cromakalin and diazoxide, drugs that activate ATP-sensitive potassium (KATP) channels, abolish hypoxic pulmonary vasoconstriction (HPV) of isolated, perfused rat lungs. 2. Glibenclamide, an inhibitor of these channels, does not affect HPV, but it reverses the relaxation caused by cromakalim and diazoxide. 3. Tolbutamide, which has effects similar to glibenclamide in other tissues, paradoxically abolishes HPV, an effect reversed by glibenclamide. 4. These results suggest that: (i… CONTINUE READING