Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.

@article{Ingram2006OpposingAO,
  title={Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.},
  author={Jennifer L Ingram and Aurita Antao-Menezes and James B. Mangum and Otis Lyght and Patty J Lee and Jack A Elias and James C. Bonner},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={4141-8}
}
IL-13 is a key cytokine involved in airway remodeling in asthma. We previously reported that IL-13 stimulated the mitogenesis of lung fibroblasts via platelet-derived growth factor (PDGF)-AA. In this report, we show that IL-13 increases PDGF-A and PDGF-C mRNA levels through a dual intracellular cascade that requires coactivation of Stat6 and Stat1 to impact transcriptional regulation of the early growth response (Egr)-1 gene, which then drives PDGF expression. Increased levels of PDGF-AA and… CONTINUE READING

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