Opposing actions of STAT-1 and STAT-3.

  title={Opposing actions of STAT-1 and STAT-3.},
  author={Anastasis Stephanou and D. S. Latchman},
  journal={Growth factors},
  volume={23 3},
The signal transducers and activators of transcription (STATs) are a family of transcription factors, which were originally identified on the basis of their ability to transduce a signal from a cellular receptor into the nucleus and modulate the transcription of specific genes. Interestingly, recent studies have demonstrated that STAT-1 plays a key role in promoting apoptosis in a variety of cell types, whereas STAT-3 has an anti-apoptotic effect. Moreover, whilst STAT-3 promotes cellular… CONTINUE READING
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