Opposing actions of D1- and D2-dopamine receptors on arachidonic acid release and cyclic AMP production in striatal neurons.

@article{Schinelli1994OpposingAO,
  title={Opposing actions of D1- and D2-dopamine receptors on arachidonic acid release and cyclic AMP production in striatal neurons.},
  author={Sergio Schinelli and Mayra Paolillo and Gian Luigi Corona},
  journal={Journal of neurochemistry},
  year={1994},
  volume={62 3},
  pages={944-9}
}
D1- and D2-dopamine receptors exert important physiological actions on striatal neurons, but the intracellular second messenger pathways activated by these receptors are still incompletely understood. Using primary cultures of rat striatal cells, we have examined the effects of activating D1 or D2 receptors on arachidonic acid (AA) release and cyclic AMP accumulation. In striatal neurons labeled by incubation with [3H]AA, D2-receptor stimulation enhanced release of [3H]AA produced by… CONTINUE READING

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