Opposing LSD1 complexes function in developmental gene activation and repression programmes

@article{Wang2007OpposingLC,
  title={Opposing LSD1 complexes function in developmental gene activation and repression programmes},
  author={Jianxun Wang and Kathleen M. Scully and Xiaoyan Zhu and Ling Cai and Jie Zhang and Gratien G. Prefontaine and Anna Krones and Kenneth a. Ohgi and Ping Zhu and Ivan Garcia-Bassets and Forrest Liu and Havilah Taylor and Jean Lozach and Friederike L Jayes and Kenneth S. Korach and Christopher K. Glass and Xiang-Dong Fu and Michael G. Rosenfeld},
  journal={Nature},
  year={2007},
  volume={446},
  pages={882-887}
}
Precise control of transcriptional programmes underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies. One thing that remains unclear is how specific members of histone modification enzyme families, such as histone methyltransferases and demethylases, are used in vivo to simultaneously orchestrate distinct developmental gene activation and repression programmes. Here, we report that the histone lysine demethylase, LSD1—a… 

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