Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

@article{Kretzschmar1997OpposingBA,
  title={Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1},
  author={M. Kretzschmar and J. Doody and J. Massagu},
  journal={Nature},
  year={1997},
  volume={389},
  pages={618-622}
}
The growth factor TGF-β, bone morphogenetic proteins (BMPs) and related factors regulate cell proliferation, differentiation and apoptosis, controlling the development and maintenance of most tissues,. Their signals are transmitted through the phosphorylation of the tumour-suppressor SMAD proteins by receptor protein serine/threonine kinases (RS/TKs), leading to the nuclear accumulation and transcriptional activity of SMAD proteins,,. Here we report that Smad1, which mediates BMP signals, is… Expand
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