Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans.

@article{Szewczyk2007OpposedGF,
  title={Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans.},
  author={Nathaniel J Szewczyk and Brant K. Peterson and Sami J Barmada and Leah P Parkinson and Lewis A. Jacobson},
  journal={The EMBO journal},
  year={2007},
  volume={26 4},
  pages={935-43}
}
In addition to contractile function, muscle provides a metabolic buffer by degrading protein in times of organismal need. Protein is also degraded during adaptive muscle remodeling upon exercise, but extreme degradation in diverse clinical conditions can compromise function(s) and threaten life. Here, we show how two independent signals interact to control protein degradation. In striated muscles of Caenorhabditis elegans, reduction of insulin-like signaling via DAF-2 insulin/IGF receptor or… CONTINUE READING
18 Citations
64 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Regulation of C

  • CA Wolkow, KD Kimura, MS Lee, G Ruvkun
  • Acta Physiol Scand
  • 2000
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…