Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

@article{Hutchings2017OpportunitiesFT,
  title={Opportunities for therapeutic antibodies directed at G-protein-coupled receptors},
  author={Catherine J. Hutchings and Markus Koglin and William C. Olson and Fiona H Marshall},
  journal={Nature Reviews Drug Discovery},
  year={2017},
  volume={16},
  pages={787-810}
}
G-protein-coupled receptors (GPCRs) are activated by a diverse range of ligands, from large proteins and proteases to small peptides, metabolites, neurotransmitters and ions. They are expressed on all cells in the body and have key roles in physiology and homeostasis. As such, GPCRs are one of the most important target classes for therapeutic drug discovery… CONTINUE READING