Opportunities for improving animal welfare in rodent models of epilepsy and seizures

@article{Lidster2016OpportunitiesFI,
  title={Opportunities for improving animal welfare in rodent models of epilepsy and seizures},
  author={K. Lidster and J. Jefferys and I. Bl{\"u}mcke and V. Crunelli and P. Flecknell and B. Frenguelli and William Gray and R. Kaminski and A. Pitk{\"a}nen and I. Ragan and M. Shah and M. Simonato and A. Trevelyan and H. Volk and M. Walker and N. Yates and M. Prescott},
  journal={Journal of Neuroscience Methods},
  year={2016},
  volume={260},
  pages={2-25}
}
Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers, and to discover new antiepileptic drugs and treatments for comorbidities. Such models represent an important area for application of the 3Rs (replacement, reduction and refinement of animal use). This report provides background information and recommendations aimed at minimising pain, suffering and… Expand
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