Opportunities for enzyme engineering in natural product biosynthesis.


Organisms from all kingdoms of life produce a plethora of natural products that display a range of biological activities. One key limitation of developing these natural products into pharmaceuticals is the inability to perform effective, fast, and inexpensive structure-activity relationship studies (SAR). Recently, enzyme engineering strategies have allowed… (More)
DOI: 10.1016/j.cbpa.2009.01.005