Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

  title={Opportunities and challenges of pluripotent stem cell neurodegenerative disease models},
  author={Jackson L. Sandoe and Kevin C. Eggan},
  journal={Nature Neuroscience},
Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-pertinent neurons both with and without predisposing mutations. While this suite of technologies has revolutionized the field of 'in vitro disease modeling', great care must be taken in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 15 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 77 extracted citations


Publications referenced by this paper.
Showing 1-10 of 107 references

motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity

  • Brockington, A. et al. Unravelling the enigma of selective vulnera neurodegeneration
  • Acta Neuropathol.125, 95–109
  • 2013

Similar Papers

Loading similar papers…