Opportunities and challenges in the development of targeted therapies.

@article{Hortobagyi2004OpportunitiesAC,
  title={Opportunities and challenges in the development of targeted therapies.},
  author={Gabriel N Hortobagyi},
  journal={Seminars in oncology},
  year={2004},
  volume={31 1 Suppl 3},
  pages={21-7}
}
Expanding knowledge about basic biology and a detailed understanding of the signaling pathways that participate in the growth and metastasis of breast cancer have identified opportunities for diagnostic and therapeutic intervention. Endocrine therapy represents the first and most successful example of targeted therapy in breast cancer. Trastuzumab (Herceptin; Genentech, Inc, South San Francisco, CA) is now part of the management of metastatic disease and is under evaluation as adjuvant therapy… CONTINUE READING

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