Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies

@article{Polvi2015OpportunisticYP,
  title={Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies},
  author={Elizabeth J. Polvi and Xinliu A. Li and Teresa R. O’Meara and Michelle D. Leach and Leah E. Cowen},
  journal={Cellular and Molecular Life Sciences},
  year={2015},
  volume={72},
  pages={2261-2287}
}
Life-threatening invasive fungal infections are becoming increasingly common, at least in part due to the prevalence of medical interventions resulting in immunosuppression. Opportunistic fungal pathogens of humans exploit hosts that are immunocompromised, whether by immunosuppression or genetic predisposition, with infections originating from either commensal or environmental sources. Fungal pathogens are armed with an arsenal of traits that promote pathogenesis, including the ability to… 
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References

SHOWING 1-10 OF 385 REFERENCES
Vaccines for invasive fungal infections
TLDR
Improved understanding of the host defense and pathogenetic mechanisms that lead to invasive fungal infections means it should be feasible to develop vaccines targeting these infections, and the antigenic repertoire available for testing should not be limited to virulence factors.
Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease
TLDR
The circuitry regulating fungal morphogenesis and drug resistance and the impact of these pathways on virulence are reviewed, which represent a minute fraction of fungal diversity.
Hidden Killers: Human Fungal Infections
TLDR
The importance of fungi as human pathogens is highlighted and the challenges the authors face in combating the devastating invasive infections caused by these microorganisms are discussed, in particular in immunocompromised individuals.
The impact of the host on fungal infections.
  • J. Perfect
  • Medicine, Biology
    The American journal of medicine
  • 2012
Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen because of its tendency to infect immunocompromised individuals, particularly those infected with HIV. However,
Cryptococcal Interactions with the Host Immune System
TLDR
The innate and adaptive immune responses to Cryptococcus and cryptococcal strategies to evade the host's defense mechanisms are discussed and the importance of these strategies in pathogenesis and the potential of immunotherapy in cryptococcosis treatment are addressed.
Candida and Host Determinants of Susceptibility to Invasive Candidiasis
TLDR
A mouse model of the infection, which introduces Candida yeast cells intravenously and mimics skin-derived bloodstream human candidiasis, has been successfully employed to study fungal and host factors that regulate susceptibility to the infection.
Innate antifungal immunity: the key role of phagocytes.
TLDR
This review covers the functions of phagocytes in innate antifungal immunity, along with selected examples of the strategies that are used by fungal pathogens to subvert these defenses.
Hyphal Growth in Human Fungal Pathogens and Its Role in Virulence
  • A. Brand
  • Biology
    International journal of microbiology
  • 2012
TLDR
Polarised hyphal growth is co-regulated with other factors that are essential for normal hypha function in vivo and is found to support the directional translocation between host environments, consolidation of the colony, nutrient acquisition and the formation of 3-dimensional matrices.
Genetic Susceptibility to Fungal Infections in Humans
  • M. Lionakis
  • Biology, Medicine
    Current Fungal Infection Reports
  • 2011
TLDR
In this review, recent developments concerning genetic and immunologic factors that affect the risk for IFIs and CMC are critically discussed.
...
...