Opponent melanopsin and S-cone signals in the human pupillary light response.

@article{Spitschan2014OpponentMA,
  title={Opponent melanopsin and S-cone signals in the human pupillary light response.},
  author={Manuel Spitschan and Sandeep Jain and David H. Brainard and Geoffrey K. Aguirre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 43},
  pages={15568-72}
}
In the human, cone photoreceptors (L, M, and S) and the melanopsin-containing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are active at daytime light intensities. Signals from cones are combined both additively and in opposition to create the perception of overall light and color. Similar mechanisms seem to be at work in the control of the pupil's response to light. Uncharacterized however, is the relative contribution of melanopsin and S cones, with their overlapping, short… CONTINUE READING