Opioids induce while nicotine suppresses apoptosis in human lung cancer cells.

@article{Maneckjee1994OpioidsIW,
  title={Opioids induce while nicotine suppresses apoptosis in human lung cancer cells.},
  author={Rhoda Maneckjee and John D. Minna},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1994},
  volume={5 10},
  pages={1033-40}
}
Previously, we have shown that opioids acting via specific receptors inhibit the growth of human lung cancer cells while nicotine, acting through nicotinic acetylcholine receptors, reverses this inhibition. Therefore, we studied the role of apoptosis in these processes. Treatment of human lung cancer cells with 0.1-1 microM morphine or methadone resulted in morphological changes and cleavage of DNA into nucleosome-sized fragments characteristic of apoptosis. Quantitation of DNA fragmentation… CONTINUE READING