Opioids in the hypothalamus control dopamine and acetylcholine levels in the nucleus accumbens.

@article{Rada2010OpioidsIT,
  title={Opioids in the hypothalamus control dopamine and acetylcholine levels in the nucleus accumbens.},
  author={Pedro V Rada and Jessica R Barson and Sarah F. Leibowitz and Bartley G. Hoebel},
  journal={Brain research},
  year={2010},
  volume={1312},
  pages={1-9}
}
The experimental question is whether hypothalamic opioids, known to stimulate consummatory behavior, control a link to the nucleus accumbens (NAc). It was hypothesized that opioids injected in the hypothalamic paraventricular nucleus (PVN) alter the balance of dopamine (DA) and acetylcholine (ACh) in the NAc in a manner that fosters appetite for food or ethanol. Rats were implanted with two guide shafts, one in the NAc to measure extracellular DA and ACh by microdialysis and the other in the… CONTINUE READING
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