Opioids in renal failure and dialysis patients.

  title={Opioids in renal failure and dialysis patients.},
  author={Mervyn M. Dean},
  journal={Journal of pain and symptom management},
  volume={28 5},
  • Mervyn M. Dean
  • Published 2004 in Journal of pain and symptom management
This article reviews the literature pertaining to the metabolism of several of the commonly used opioids, and the known activity of their metabolites. The effect of renal failure on the pharmacokinetics of these drugs and metabolites is then reviewed. Finally, the effect of renal dialysis on opioid drugs and metabolites is reviewed. Based on the review, it is recommended that morphine and codeine are avoided in renal failure/dialysis patients; hydromorphone or oxycodone are used with caution… CONTINUE READING

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Neuroexcitatory effects of morphine and hydromorphone: Evidence for implicating the 3glucuronide metabolites

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The renal drug handbook

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