Opioids for Chronic Noncancer Pain: Still No Evidence for Superiority of Sustained‐Release Opioids

  title={Opioids for Chronic Noncancer Pain: Still No Evidence for Superiority of Sustained‐Release Opioids},
  author={Line Pedersen and O M S Fredheim},
  journal={Clinical Pharmacology \& Therapeutics},
Opioids are controversial in the treatment of chronic pain due to the risk of addiction, misuse, and death. Long‐acting formulations of opioids have been hypothesized to improve pain relief, sleep quality, and lower the risk of side effects and addiction compared to short‐acting formulations of opioids. Thus, several guidelines have recommended the use of long‐acting opioid formulations over short‐acting ones in the treatment of chronic noncancer pain. However, is there really evidence of their… 
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