Opioids are non-competitive inhibitors of nitric oxide synthase in T47D human breast cancer cells

@article{Kampa2001OpioidsAN,
  title={Opioids are non-competitive inhibitors of nitric oxide synthase in T47D human breast cancer cells},
  author={Marilena Kampa and Anastassia Hatzoglou and Georgios Notas and Maria Niniraki and Elias Kouroumalis and Elias Castanas},
  journal={Cell Death and Differentiation},
  year={2001},
  volume={8},
  pages={943-952}
}
Opioids and nitric oxide (NO) interact functionally in different systems. NO-generating agents decrease the activity of opioid agonists, prevent opioid tolerance, and are used in opioid withdrawal syndromes. There exist, however, few reports indicating a direct interaction of the two systems. T47D human breast cancer cells in culture express opioid receptors, and opioid agonists inhibit their growth, while they release high amounts of the NO-related molecules NO2−/NO3− to the culture medium. We… CONTINUE READING
8 Citations
84 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 84 references

Jand Leza JC(2000)Up-regulation ofneuronalNO synthase immunoreactivity in opiate dependence and withdrawal

  • B Cuellar, AP Fernandez, +4 authors Rodrigo
  • Psychopharmacology (Berl). 148:
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…