Opioids and skin homeostasis, regeneration and ageing - What's the evidence?

@article{Bigliardi2016OpioidsAS,
  title={Opioids and skin homeostasis, regeneration and ageing - What's the evidence?},
  author={Paul Lorenz Bigliardi and Y Dancik and Christine Neumann and Mei Bigliardi-Qi},
  journal={Experimental dermatology},
  year={2016},
  volume={25 8},
  pages={
          586-91
        }
}
What has the opioid receptor system, known for beneficial as well as disastrous effects in the central nervous system, to do with skin? The question is appropriate considering the fact that the nervous system and the skin both derive from the ectoderm. As part of the skin neuroendocrine system, the opioid receptor system exemplifies the closeness between the nervous system and the skin. Overexpression of the δ-opioid receptor in keratinocytes yields dysregulation of involucrin, loricrin, and… CONTINUE READING
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