Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.

@article{Armstead1995OpioidsAN,
  title={Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.},
  author={William M Armstead},
  journal={The American journal of physiology},
  year={1995},
  volume={268 1 Pt 2},
  pages={H226-32}
}
The present study was designed to investigate the contribution of opioids and nitric oxide (NO) to hypoxia-induced pial vasodilation. Newborn pigs equipped with a closed cranial window were used to measure pial arteriolar diameter and to collect cortical periarachnoid cerebrospinal fluid (CSF) for assay of opioids and guanosine 3',5'-cyclic monophosphate (cGMP). Hypoxia-induced pial dilation was potentiated by norbinaltorphimine, 10(-6) M, a kappa-opioid antagonist (25 +/- 2 vs. 33 +/- 3%, n… CONTINUE READING
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