Opioids and myocardial reperfusion injury.

  title={Opioids and myocardial reperfusion injury.},
  author={Garrett Gross and Jason N. Peart},
  journal={Archives des maladies du coeur et des vaisseaux},
  volume={100 3},
It is well-established that reperfusion is the major method of salvaging ischemic myocardium following prolonged coronary artery occlusion, although the idea of reperfusion injury remains controversial. Moreover, more recent evidence strongly suggests that reperfusion per se is thought to result in further damage to the myocardium and blood vessel endothelium by various biochemical and physical factors including a burst of oxygen-derived free radicals (ROS), cellular or mitochondrial calcium… CONTINUE READING
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