Opioids and intake of alcoholic beverages.


Rats were given a daily opportunity to consume a sweetened ethanol solution (ES) or water until they took about 2.0 g/kg of pure ethanol (E) during 1.5 hr/day. Then, rats were given one of a number of opioids before an opportunity to drink. Some opioids, e.g., morphine (MOR), methadone, and fentanyl, at small doses, increase ES-intake; some decrease intakes, e.g., naloxone (NX) and MR 2266. Diprenorphine, a mixed agonist-antagonist having no analgesic potential and blocking other opioids' analgesia, increases ES-intake across a wide range of doses beginning with 0.003 mg/kg.


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@article{Reid1986OpioidsAI, title={Opioids and intake of alcoholic beverages.}, author={Larry D. Reid and S A Czirr and W C Milano and Christopher L Hubbell and N A Manha}, journal={NIDA research monograph}, year={1986}, volume={75}, pages={359-62} }