Opioids and hibernation. I. Effects of naloxone on bear HIT'S depression of guinea pig ileum contractility and on induction of summer hibernation in the ground squirrel.

@article{Bruce1987OpioidsAH,
  title={Opioids and hibernation. I. Effects of naloxone on bear HIT'S depression of guinea pig ileum contractility and on induction of summer hibernation in the ground squirrel.},
  author={David S. Bruce and G W Cope and T R Elam and K A Ruit and Peter Rudolf Oeltgen and T P Su},
  journal={Life sciences},
  year={1987},
  volume={41 18},
  pages={
          2107-13
        }
}
Summer hibernation in ground squirrels (Citellus tridecemlineatus) can be induced by intravenous injection of hibernation-induction trigger (HIT) from winter bear plasma or its albumin fraction. In this study, we show that bear HIT depresses electrically-induced contraction of the guinea pig ileum myenteric plexus-longitudinal muscle preparation, and that naloxone, at 100, 1,000, or even 4,000 nM, fails to reverse that effect. In a simultaneous study, four sets of ground squirrels were… CONTINUE READING

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