Opioids affect acquisition of LiCl-induced conditioned taste aversion: involvement of OT and VP systems.

@article{Olszewski2000OpioidsAA,
  title={Opioids affect acquisition of LiCl-induced conditioned taste aversion: involvement of OT and VP systems.},
  author={Pawel K Olszewski and Qiuying Shi and Charles J. Billington and Allen S. Levine},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={279 4},
  pages={
          R1504-11
        }
}
  • P. Olszewski, Q. Shi, +1 author A. Levine
  • Published 1 October 2000
  • Biology, Psychology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Aversive properties of lithium chloride (LiCl) are mediated via pathways comprising neurons of the nucleus of the solitary tract (NTS) and oxytocin (OT) and vasopressin (VP) cells in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Because opioids act on brain regions that mediate effects of LiCl, we evaluated whether administration of opioids shortly before LiCl in rats influences 1) development of conditioned taste aversion (CTA) and 2) activation of NTS neurons and OT/VP… 

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