Opioid treatment for acute and chronic pain in patients with sickle cell disease

  title={Opioid treatment for acute and chronic pain in patients with sickle cell disease},
  author={C. P. Carroll},
  journal={Neuroscience Letters},
Sickle cell disease is a uniquely complex painful disease, with lifelong episodes of unpredictable acute pain and superimposed chronic pain in adulthood. Both painful crises and chronic pain in sickle cell disease lack strong objective pathological correlates and their mechanisms are poorly understood. Opioids have emerged as the standard of care for severe acute pain in sickle cell disease and many patients with chronic pain are maintained on chronic opioid therapy. The strong association… Expand
4 Citations
Pain Experiences of Adults With Sickle Cell Disease and Hematopoietic Stem Cell Transplantation: A Qualitative Study.
Clinicians should use a patient-centered approach, integrating non-opioid approaches into pain management, particularly psychosocial support as transplant for SCD becomes increasingly available, to improve health care delivery and overall patient experiences. Expand
Patient with Sickle Cell Disease
The goal of this chapter is to provide an overview of the disease processes that drive the clinical manifestations of pain in sickle cell disease and draw attention to the distinct elements of managing the disease. Expand
A Pilot Study of the Acceptability, Feasibility and Safety of Yoga for Chronic Pain in Sickle Cell Disease.
Patients with SCD and chronic pain overall have a positive opinion of yoga, but there are challenges with recruitment and retention of participants in a clinical trial of Yoga, and barriers to feasibility of an in-person group yoga intervention. Expand
Buprenorphine for chronic pain in a pediatric patient with sickle-cell disease.


Chronic Opioid Therapy and Central Sensitization in Sickle Cell Disease.
Overall, the results point out a high symptom burden in SCD patients on COT, including those on high-dose Cot, and suggest that nociceptive processing in SCd patients onCOT differs from those who are not. Expand
Detecting the emergence of chronic pain in sickle cell disease.
Most SCD patients whose pain remits entirely between episodes are not in a chronic pain state, but some--those who are older and have a history of highly painful episodes--appear to be transitioning into it, and early signs of disturbed processing may aid clinicians seeking to forestall disease progression. Expand
Chronic pain persists in adults with sickle cell disease despite regular red cell transfusions.
  • M. Karafin, Danielle E Mullins, +4 authors J. Field
  • Medicine
  • Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • 2019
These results suggest that, even with regular transfusions and a low HbS, daily pain persists in many adults with SCD. Expand
Patterns of opioid use in sickle cell disease
D doses and types of opioid medications used by adult SCD patients vary widely, and findings implicate AVN and lower vitamin D levels as factors associated with higher opioid use, suggesting an association of higher bilirubin levels and higher hemolytic rate with lower opioid use. Expand
Daily Assessment of Pain in Adults with Sickle Cell Disease
The relationship among self-reported pain, crises, and health care utilization for pain in a cohort study of patients with sickle cell disease was examined, with particular emphasis on potentially mutable, causal, nonbiological variables. Expand
Pain and opioid use after reversal of sickle cell disease following HLA‐matched sibling haematopoietic stem cell transplant
The prevalence and correlates of pain requiring continued opioid treatment at 12 months after successful non-myeloablative human leucocyte antigen-matched sibling allogeneic HSCT in a cohort of SCD patients are determined. Expand
Neurobiological mechanisms of pain in sickle cell disease.
The latest evidence from the authors' studies suggests that these pathways are important for SCD pain, and can now start to elucidate neurobiological mechanisms underlying pain in SCD, which may lead to better understanding and effective therapies. Expand
Daily home opioid use in adults with sickle cell disease: The PiSCES project.
Pain was the overwhelming characteristic associated with use, but disease-related and psychosocial variables were also associated, and opioids were used by the majority of patients. Expand
Pain and Opioid Use after Reversal of Sickle Cell Disease Following Hematopoietic Stem Cell Transplant
SCD patients with higher pre-HSCT pain burden (more pain admissions and higher pain intensity ratings), long-acting opioid use and certain psychological traits (anxious disposition) may be at risk for persistent pain and continued opioid use after a successful HSCT. Expand
Pain site frequency and location in sickle cell disease: The PiSCES project
Identification and understanding of combinations of pain location and intensity may help to understand the etiology of SCD and improve SCD management. Expand