Opioid switching to improve pain relief and drug tolerability.

  title={Opioid switching to improve pain relief and drug tolerability.},
  author={Columba Quigley},
  journal={The Cochrane database of systematic reviews},
  • Columba Quigley
  • Published 2004 in The Cochrane database of systematic reviews
BACKGROUND Patients with cancer, and increasingly chronic non-cancer pain frequently require strong opioids for pain relief. Morphine is the first-line strong opioid of choice for these patients. While most achieve adequate analgesia with morphine, a significant minority either suffer intolerable side-effects, inadequate pain relief, or both. For these patients switching to an alternative opioid is becoming established clinical practice. However, the evidence for the effectiveness of opioid… CONTINUE READING

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