Opioid subtype- and cell-type-dependent regulation of inhibitory synaptic transmission in the rat insular cortex.

@article{Yokota2016OpioidSA,
  title={Opioid subtype- and cell-type-dependent regulation of inhibitory synaptic transmission in the rat insular cortex.},
  author={Eiko Yokota and Yuko Koyanagi and Kiyofumi Yamamoto and Yoshiyuki Oi and Noriaki Koshikawa and Masayuki Kobayashi},
  journal={Neuroscience},
  year={2016},
  volume={339},
  pages={478-490}
}
The insular cortex (IC) plays a principal role in the regulation of pain processing. Although opioidergic agonists depress cortical excitatory synaptic transmission, little is known about opioidergic roles in inhibitory synaptic transmission. In the IC, the opioid receptors differentially regulate the excitatory propagation: agonists of the mu (MOR), delta (DOR), and kappa (KOR) exhibit suppressive, facilitative, and little effects, respectively. Thus, we aimed to examine the effects of opioid… CONTINUE READING
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Opioid receptors. Continuing Education in Anaesthesia, Critical Care & Pain 5:22-25

  • J McDonald, DG Lambert
  • 2005
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