Opioid rotation for cancer pain: rationale and clinical aspects.

@article{Mercadante1999OpioidRF,
  title={Opioid rotation for cancer pain: rationale and clinical aspects.},
  author={Sebastiano L Mercadante},
  journal={Cancer},
  year={1999},
  volume={86 9},
  pages={1856-66}
}
BACKGROUND Some patients with cancer pain may develop uncontrolled adverse effects, including generalized myoclonus, delirium, nausea and emesis, or severe sedation before achieving adequate analgesia during opioid dose titration. Sequential therapeutic trials should be considered to determine the most favorable drug. METHODS Recent literature was taken into account when reviewing the rationale and potential of opioid rotation. RESULTS When aggressive attempts to prevent adverse effects… CONTINUE READING
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