Opioid regulation of hypothalamic-pituitary-adrenal function in depression.

Abstract

A morphine infusion paradigm was used to investigate opioid mechanisms in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis in depression. The subjects were unmedicated psychiatric inpatients and healthy volunteers. Morphine suppressed cortisol secretion. Early resumption of cortisol secretion was associated with a diagnosis of major… (More)

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@article{Zis1985OpioidRO, title={Opioid regulation of hypothalamic-pituitary-adrenal function in depression.}, author={Athanasios P. Zis and Roger F. Haskett and A. Ariav Albala and Brendan J. Carroll and N E Lohr}, journal={Archives of general psychiatry}, year={1985}, volume={42 4}, pages={383-6} }