Opioid regimens in patients with chronic pain with multiple cytochrome P450 defects.

@article{Tennant2015OpioidRI,
  title={Opioid regimens in patients with chronic pain with multiple cytochrome P450 defects.},
  author={Forest S. Tennant},
  journal={Journal of opioid management},
  year={2015},
  volume={11 3},
  pages={
          237-42
        }
}
There is a subgroup of patients with chronic pain who have multiple cytochrome P450 enzyme defects. These patients tend to use opioids that are not metabolized by the CYP450 system and most apparently require a higher than average dosage. A significant number require nonoral administration. 

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