Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells

  title={Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells},
  author={Romana {\vS}{\'i}nov{\'a} and Jana Kudov{\'a} and Kristina Ne{\vs}porov{\'a} and Sergej Karel and Romana {\vS}ul{\'a}kov{\'a} and Vladim{\'i}r Velebn{\'y} and Luk{\'a}{\vs} Kubala},
  journal={Journal of Cellular Physiology},
  pages={13209 - 13219}
The stimulation of myocardium repair is restricted due to the limited understanding of heart regeneration. Interestingly, endogenous opioid peptides such as dynorphins and enkephalins are suggested to support this process. However, the mechanism—whether through the stimulation of the regenerative capacity of cardiac stem cells or through effects on other cell types in the heart—is still not completely understood. Thus, a model of the spontaneous cardiomyogenic differentiation of mouse embryonic… Expand
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