Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells

@article{nov2019OpioidRA,
  title={Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells},
  author={Romana {\vS}{\'i}nov{\'a} and Jana Kudov{\'a} and Kristina Ne{\vs}porov{\'a} and Sergej Karel and Romana {\vS}ul{\'a}kov{\'a} and Vladim{\'i}r Velebn{\'y} and Luk{\'a}{\vs} Kubala},
  journal={Journal of Cellular Physiology},
  year={2019},
  volume={234},
  pages={13209 - 13219}
}
The stimulation of myocardium repair is restricted due to the limited understanding of heart regeneration. Interestingly, endogenous opioid peptides such as dynorphins and enkephalins are suggested to support this process. However, the mechanism—whether through the stimulation of the regenerative capacity of cardiac stem cells or through effects on other cell types in the heart—is still not completely understood. Thus, a model of the spontaneous cardiomyogenic differentiation of mouse embryonic… Expand
Regulation of Cardiomyocyte Differentiation, Angiogenesis, and Inflammation by the Delta Opioid Signaling in Human Mesenchymal Stem Cells
  • L. Reddy, D. Sen
  • Biology
  • Regenerative Engineering and Translational Medicine
  • 2019
TLDR
Results indicate that, upon activation of delta opioid receptors on human umbilical cord derived mesenchymal stem cells, they can differentiate into heart cells (by expressing specific markers GATA4, MEF2C, Connexin43), show enhanced formation of blood vessels and anti-inflammatory activity. Expand
Nitro-Oleic Acid Inhibits Stemness Maintenance and Enhances Neural Differentiation of Mouse Embryonic Stem Cells via STAT3 Signaling
TLDR
NO2-OA is able to modulate pluripotency of mESC via the regulation of STAT3 phosphorylation, and attenuates cardiac differentiation on the one hand, and on the other hand, it directs m ESC into neural fate. Expand
κ-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway.
TLDR
Evidence is provided for the first time that κ-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to MI/R injury via STAT3-OPA1 pathway. Expand
Prospective oncotarget for gynecological cancer: Opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.
TLDR
The OGF - OGFr axis provides significant strategies for antitumor efficiency in gynecological cancer, and immune augmentation combination therapies can intensify cytotoxic activity, but OGF or OGFr antagonists do not increase toxicities associated with dual-immune regulation. Expand
Mechanisms Inspired Targeting Peptides.
  • Yunsheng Yuan
  • Medicine, Chemistry
  • Advances in experimental medicine and biology
  • 2020
Peptides, as a large group of molecules, are composed of amino acid residues and can be divided into linear or cyclic peptides according to the structure. Over 13,000 molecules of natural peptidesExpand
Conventional Echocardiography and Two-Dimensional Speckle Tracking in Healthy Sevoflurane-Anesthetized Dogs Undergoing Continuous Rate Infusion of Nalbuphine
TLDR
Nalbuphine given at a CRI does not influence left ventricular systolic and diastolic function in healthy sevoflurane-anesthetized dogs, and the E′/A′ ratio significantly increased at 20 minutes compared to baseline only in GN. Expand
Regulation of Cancer Immune Checkpoints: Molecular and Cellular Mechanisms and Therapy
Cancer immunotherapy, especially immune checkpoint blockade therapy, represents a hotspot in cancer research. However, the low response rate, adaptive/acquired resistance, and adverse effects stillExpand

References

SHOWING 1-10 OF 47 REFERENCES
Opioid Peptide Gene Expression Primes Cardiogenesis in Embryonal Pluripotent Stem Cells
Abstract—Zinc finger–containing transcription factor GATA-4 and homeodomain Nkx-2.5 govern crucial developmental fates and have been found to promote cardiogenesis in embryonic cells exposed to theExpand
Opioid peptide gene expression primes cardiogenesis in embryonal pluripotent stem cells.
TLDR
Opioid receptor antagonism and inhibition of opioid gene expression by a prodynorphin antisense phosphorothioate oligonucleotide blocked DMSO-induced cardiogenesis, suggesting an autocrine role of an opioid gene in developmental decisions. Expand
Morphine sulfate concomitantly decreases neuronal differentiation and opioid receptor expression in mouse embryonic stem cells.
TLDR
Investigating the impact of morphine sulfate treatment on neuronal differentiation as well as μ-opioid receptor (MOR) expression in mouse embryonic stem (mES) cells shows that MS exposure at early and late stage of cellular differentiation significantly decreases genotype and phenotype in differentiated neuronal cells. Expand
Cardiomyogenic stem and progenitor cell plasticity and the dissection of cardiopoiesis.
TLDR
The study of stem and progenitor cells has provided important insights into the process of cardiomyogenesis, and it is likely that future research in this area will turn the promise of repairing an injured heart into a reality. Expand
Dynorphin B Is an Agonist of Nuclear Opioid Receptors Coupling Nuclear Protein Kinase C Activation to the Transcription of Cardiogenic Genes in GTR1 Embryonic Stem Cells
Abstract— The cardiac differentiation of embryonic stem (ES) cells was found to involve prodynorphin gene and dynorphin B expression and was associated with the interaction of secreted dynorphin BExpand
The κ opioid system regulates endothelial cell differentiation and pathfinding in vascular development.
TLDR
The opioid system is a new regulator of vascular development that simultaneously modifies 2 distinct vascular properties, EC differentiation and vascular pathfinding. Expand
Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis
TLDR
The presence of active mu-, delta- and kappa-opioid receptors in mouse male germ cells are reported for the first time and show an exposition time-dependent response to opioid agonist, hence suggesting their active involvement in spermatogenesis. Expand
The acceleration of cardiomyogenesis in embryonic stem cells in vitro by serum depletion does not increase the number of developed cardiomyocytes
TLDR
Modifications of the basic protocol for ES cell differentiation into cardiomyocytes were evaluated in order to increase the yield and differentiation status of developed cardiomers, and serum depletion was identified as a key factor that intensifiedCardiomyogenesis under serum depleted conditions. Expand
Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster
TLDR
Exogenous dynorphin B induced a dose-dependent increase in prodynorphin mRNA levels and stimulated prodynoirin gene transcription in normal hamster myocytes and similar responses were elicited by the synthetic selective κ opioid receptor agonist U-50,488H. Expand
Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster
TLDR
KC activation and intracellular Ca2+ overload may represent the two major signaling mechanisms involved in the induction of the prodynorphin gene in cardiomyopathic cells. Expand
...
1
2
3
4
5
...