Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects

  title={Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects},
  author={M. Busch-Dienstfertig and C. Stein},
  journal={Brain, Behavior, and Immunity},
  • M. Busch-Dienstfertig, C. Stein
  • Published 2010
  • Medicine
  • Brain, Behavior, and Immunity
  • This review summarizes recent findings on neuro-immune mechanisms underlying opioid-mediated inhibition of pain. The focus is on events occurring in peripheral injured tissues that lead to the sensitization and excitation of primary afferent neurons, and on the modulation of such mechanisms by immune cell-derived opioid peptides. Primary afferent neurons are of particular interest from a therapeutic perspective because they are the initial generators of impulses relaying nociceptive information… CONTINUE READING
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