Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects

@article{BuschDienstfertig2010OpioidRA,
  title={Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects},
  author={Melanie Busch-Dienstfertig and Christoph Stein},
  journal={Brain, Behavior, and Immunity},
  year={2010},
  volume={24},
  pages={683-694}
}
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Bidirectional Regulation of Opioid and Chemokine Function
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The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and
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References

SHOWING 1-10 OF 218 REFERENCES
Peripheral mechanisms of pain and analgesia
Immune cell-derived opioids protect against neuropathic pain in mice.
TLDR
It is demonstrated that leukocytes containing opioids are essential regulators of pain in a mouse model of neuropathy, and selective targeting of opioid-containing immune cells promotes endogenous pain control and offers novel opportunities for management of painful neuropathies.
Peripheral mechanisms of opioid analgesia.
Modulation of Peripheral Endogenous Opioid Analgesia by Central Afferent Blockade
TLDR
These findings suggest an interplay of central and peripheral mechanisms of pain control and an effective central inhibition of pain apparently signals a reduced need for recruitment of opioid-containing immune cells to injured sites.
Neurokinin-1 Receptor Antagonists Inhibit the Recruitment of Opioid-containing Leukocytes and Impair Peripheral Antinociception
TLDR
Endogenous inhibition of inflammatory pain is dependent on NK1 receptor–mediated recruitment of opioid-containing leukocytes and stress-induced antinociception.
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
TLDR
In vivo and in vitro findings suggest that IL-1 and CRF activate their receptors on immune cells to release opioids that subsequently occupy multiple opioid receptors on sensory nerves and result in antinociception.
Rapid Modulation of μ-Opioid Receptor Signaling in Primary Sensory Neurons
TLDR
The results indicate that μ-opioid receptor signaling in primary sensory TG neurons is enhanced by activation of phospholipase C-coupled receptors via a cyclooxygenase-dependent AA metabolite that is downstream of PKC.
Opioid Peptide–expressing Leukocytes: Identification, Recruitment, and Simultaneously Increasing Inhibition of Inflammatory Pain
TLDR
The degree of endogenous pain inhibition is proportional to the number of opioid peptide–producing cells, and distinct leukocyte lineages contribute to this function at different stages of inflammation.
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