Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects

@article{BuschDienstfertig2010OpioidRA,
  title={Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects},
  author={M. Busch-Dienstfertig and C. Stein},
  journal={Brain, Behavior, and Immunity},
  year={2010},
  volume={24},
  pages={683-694}
}
  • M. Busch-Dienstfertig, C. Stein
  • Published 2010
  • Medicine
  • Brain, Behavior, and Immunity
    • This review summarizes recent findings on neuro-immune mechanisms underlying opioid-mediated inhibition of pain. The focus is on events occurring in peripheral injured tissues that lead to the sensitization and excitation of primary afferent neurons, and on the modulation of such mechanisms by immune cell-derived opioid peptides. Primary afferent neurons are of particular interest from a therapeutic perspective because they are the initial generators of impulses relaying nociceptive information… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 217 REFERENCES
    Targeting of opioid-producing leukocytes for pain control
    • 69
    Peripheral mechanisms of pain and analgesia
    • 221
    Different mechanisms of intrinsic pain inhibition in early and late inflammation
    • 107
    Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation.
    • 535
    • PDF
    Immune cell-derived opioids protect against neuropathic pain in mice.
    • 79
    • PDF
    Peripheral mechanisms of opioid analgesia.
    • 183
    Painful inflammation-induced increase in mu-opioid receptor binding and G-protein coupling in primary afferent neurons.
    • 178
    • PDF
    Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
    • 281
    • PDF
    Topical and Peripherally Acting Analgesics
    • 311
    • PDF
    Opioid Peptide–expressing Leukocytes: Identification, Recruitment, and Simultaneously Increasing Inhibition of Inflammatory Pain
    • 198