Opioid receptors and cardioprotection - 'opioidergic conditioning' of the heart.

  title={Opioid receptors and cardioprotection - 'opioidergic conditioning' of the heart.},
  author={John P Headrick and Louise See Hoe and Eugene Francois du Toit and Jason N. Peart},
  journal={British journal of pharmacology},
  volume={172 8},
Ischaemic heart disease (IHD) remains a major cause of morbidity/mortality globally, firmly established in Westernized or 'developed' countries and rising in prevalence in developing nations. Thus, cardioprotective therapies to limit myocardial damage with associated ischaemia-reperfusion (I-R), during infarction or surgical ischaemia, is a very important, although still elusive, clinical goal. The opioid receptor system, encompassing the δ (vas deferens), κ (ketocyclazocine) and μ (morphine… CONTINUE READING


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