Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3.

@article{Schulz2002OpioidRT,
  title={Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3.},
  author={R{\"u}diger Schulz and Andrea Wehmeyer and Karin Schulz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={300 2},
  pages={376-84}
}
Activation of G protein-coupled receptors (GPCRs) may bring about their disappearance from the cell membrane, and it is commonly accepted that G protein-coupled receptor kinases (GRKs) play a key function in this mechanism. Opioid receptors belong to the family of GPCRs and are substrates of GRKs. We examined the fate of delta- and mu-opioid receptors and GRK2 and 3 in living cells during the process of receptor sequestration, using laser scanning microscopy. For visualization purposes… CONTINUE READING