Opioid receptor signaling: relevance for gastrointestinal therapy.

  title={Opioid receptor signaling: relevance for gastrointestinal therapy.},
  author={Laura M Bohn and Kirsten M. Raehal},
  journal={Current opinion in pharmacology},
  volume={6 6},
Opiate drugs, such as morphine, are renowned for their analgesic properties. To date, opioid narcotics represent the largest and most potent class of pain relievers available to treat both acute and chronic pain conditions. The use of opiates, however, is severely limited by several adverse side effects. Upon chronic use, opiates can produce tolerance, physical dependence and addiction. Although these conditions warrant consideration, there are acute effects that present more immediate concerns… CONTINUE READING