Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
@article{Chajra2015OpioidRD, title={Opioid receptor delta as a global modulator of skin differentiation and barrier function repair}, author={Hanane Chajra and B J Amstutz and Kuno Schweikert and Daniel Henri Auriol and G{\'e}rard Redziniak and Fabrice Lef{\`e}vre}, journal={International Journal of Cosmetic Science}, year={2015}, volume={37} }
The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin‐5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in…
11 Citations
Cutaneous Opioid Receptors and Stress Responses: Molecular Interactions and Opportunities for Therapeutic Intervention
- Biology, Medicine
- 2016
Findings on the cutaneous opioid system concerning the treatment of skin pain, itching, wound healing, homeostasis, and ageing will be discussed and open opportunities for medical and cosmetic applications will be suggested.
Opioids and skin homeostasis, regeneration and ageing – What's the evidence?
- Biology, MedicineExperimental dermatology
- 2016
Evidence is presented for the fundamental role of the skin opioid receptor system in skin homeostasis, regeneration and ageing through regulation of cytokeratin 16 and TGF‐β type II receptor expression in keratinocytes.
Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides
- Biology, ChemistryEuropean Neuropsychopharmacology
- 2019
Rubsicolins are naturally occurring G-protein-biased delta opioid receptor peptides
- Biology, ChemistrybioRxiv
- 2018
The first report of naturally occurring peptides that selectively activate G-protein signaling pathways with minimal β-arrestin recruitment is presented, and it is found that rubiscolin peptides, which are produced as cleavage products of the plant protein rubisco, bind to andactivate G- protein signaling at δ opioid receptors.
Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells
- BiologyJournal of cellular physiology
- 2019
The overall data do not support the notion that opioid peptides have a significant potential to promote the spontaneous cardiomyogenesis of mES cells in vitro.
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.
- BiologyRSC medicinal chemistry
- 2021
This review comprises a comprehensive overview of biased ligands in addition to their bias factors at individual members of the opioid family of receptors, as well as bifunctional ligands.
Progress in the development of more effective and safer analgesics for pain management.
- BiologyEuropean journal of medicinal chemistry
- 2019
Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects
- BiologyPeptides
- 2015
Rubiskoliny – biologiczne aktywne peptydy pochodzenia roślinnego* Rubiscolins: Biologically active peptides of plant origin
- 2020
Dwa peptydy opioidowe pochodzenia naturalnego, które wykazują wysokie powinowactwo i wybiórczość w stosunku do receptora opioidowego typu δ, rubiskolina-5 i -6, zostały wyizolowane ze szpinaku w 2001…
References
SHOWING 1-10 OF 48 REFERENCES
Deletion of delta-opioid receptor in mice alters skin differentiation and delays wound healing.
- BiologyDifferentiation; research in biological diversity
- 2006
An essential role of DOR is suggested in skin differentiation, proliferation, and migration, factors that are important for wound healing, in mouse skin and human skin cultured fibroblasts and keratinocytes using RT-PCR.
Deletion of δ-opioid receptor in mice alters skin differentiation and delays wound healing
- Biology
- 2006
The expression of DOR is shown in mouse skin and human skin cultured fibroblasts and keratinocytes using RT-PCR to suggest an essential role in skin differentiation, proliferation, and migration, factors that are important for wound healing.
Trafficking of central opioid receptors and descending pain inhibition
- BiologyMolecular pain
- 2007
Current understanding of the mechanisms underlying GPCRs and DOR membrane trafficking are reviewed, and the analgesic function of emerged DOR through membrane trafficking under certain pathophysiological circumstances is reviewed.
Ligand stabilization of CXCR4/δ‐opioid receptor heterodimers reveals a mechanism for immune response regulation
- Biology, ChemistryEuropean journal of immunology
- 2008
It is shown that in immune cells expressing CXCR4 and DOR, simultaneous addition of their ligands CXCL12 and [D‐Pen2, D‐Pen5]enkephalin does not trigger receptor function, and this is compatible with a model in which GPCR oligomerization leads to suppression of signaling, promoting a dominant negative effect.
In Vivo Delta Opioid Receptor Internalization Controls Behavioral Effects of Agonists
- BiologyPloS one
- 2009
Overall these results establish that, in the context of pain control, receptor localization fully controls receptor function in vivo, and has both fundamental and therapeutic implications for slow-recycling GPCRs.
A delta2-opioid agonist inhibits p38 MAPK and suppresses activation of murine macrophages.
- Biology, MedicineThe Journal of surgical research
- 2005
Opioids and the skin – where do we stand?
- BiologyExperimental dermatology
- 2009
This review attempts to weave a thread around available data to discuss how the peripheral opioid system may impact on different key players in skin physiology and pathology.
Rapid heterologous desensitization of antinociceptive activity between mu or delta opioid receptors and chemokine receptors in rats.
- Biology, PsychologyDrug and alcohol dependence
- 2007
κ‐Opioid receptor‐transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments
- Biology, ChemistryFEBS letters
- 1995
Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2002
It is proposed that the activation of proinflammatory chemokine receptors down-regulates the analgesic functions of opioid receptors, and this enhances the perception of pain at inflammatory sites.