Opioid receptor delta as a global modulator of skin differentiation and barrier function repair

@article{Chajra2015OpioidRD,
  title={Opioid receptor delta as a global modulator of skin differentiation and barrier function repair},
  author={Hanane Chajra and B J Amstutz and Kuno Schweikert and Daniel Henri Auriol and G{\'e}rard Redziniak and Fabrice Lef{\`e}vre},
  journal={International Journal of Cosmetic Science},
  year={2015},
  volume={37}
}
The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin‐5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in… 
Cutaneous Opioid Receptors and Stress Responses: Molecular Interactions and Opportunities for Therapeutic Intervention
TLDR
Findings on the cutaneous opioid system concerning the treatment of skin pain, itching, wound healing, homeostasis, and ageing will be discussed and open opportunities for medical and cosmetic applications will be suggested.
Opioids and skin homeostasis, regeneration and ageing – What's the evidence?
TLDR
Evidence is presented for the fundamental role of the skin opioid receptor system in skin homeostasis, regeneration and ageing through regulation of cytokeratin 16 and TGF‐β type II receptor expression in keratinocytes.
Rubsicolins are naturally occurring G-protein-biased delta opioid receptor peptides
TLDR
The first report of naturally occurring peptides that selectively activate G-protein signaling pathways with minimal β-arrestin recruitment is presented, and it is found that rubiscolin peptides, which are produced as cleavage products of the plant protein rubisco, bind to andactivate G- protein signaling at δ opioid receptors.
Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells
TLDR
The overall data do not support the notion that opioid peptides have a significant potential to promote the spontaneous cardiomyogenesis of mES cells in vitro.
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.
TLDR
This review comprises a comprehensive overview of biased ligands in addition to their bias factors at individual members of the opioid family of receptors, as well as bifunctional ligands.
Endogenous Opiates and Behavior: 2015
Rubiskoliny – biologiczne aktywne peptydy pochodzenia roślinnego* Rubiscolins: Biologically active peptides of plant origin
Dwa peptydy opioidowe pochodzenia naturalnego, które wykazują wysokie powinowactwo i wybiórczość w stosunku do receptora opioidowego typu δ, rubiskolina-5 i -6, zostały wyizolowane ze szpinaku w 2001
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