Opioid receptor blockade during prenatal life modifies postnatal behavioral development.

@article{Mclaughlin1997OpioidRB,
  title={Opioid receptor blockade during prenatal life modifies postnatal behavioral development.},
  author={P J Mclaughlin and Sharon Tobias and Cathy Lang and Ian S. Zagon},
  journal={Pharmacology, biochemistry, and behavior},
  year={1997},
  volume={58 4},
  pages={1075-82}
}
The ontogeny of physical characteristics, spontaneous motor, and sensorimotor behaviors of preweaning rats, as well as ambulation and emotionality at weaning (day 21) were studied in rats exposed to 50 mg/kg naltrexone (NTX) or saline (controls) daily throughout gestation by maternal administration; all animals were cross-fostered to untreated mothers at birth. Morphine challenge tests and nociceptive measures revealed that this dosage of opioid antagonist blocked opioid receptors for 24 h. At… CONTINUE READING
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