Opioid modulation of the micturition reflex at the level of the pontine micturition center.

@article{Noto1991OpioidMO,
  title={Opioid modulation of the micturition reflex at the level of the pontine micturition center.},
  author={Hiroko Noto and James R. Roppolo and William Chet de Groat and Osamu Ishizaki Nishizawa and Kimio Sugaya and Satoko Tsuchida},
  journal={Urologia internationalis},
  year={1991},
  volume={47 Suppl 1},
  pages={19-22}
}
In precollicular decerebrate cats and dogs the intravenous administration of naloxone reduced urinary bladder capacity. Successive cystometrograms revealed that naloxone in doses of 10-100 micrograms/kg i.v. reduced the volume necessary to evoke micturition by 21-67% (mean 48%) in cats and 15-81% (mean 43%) in dogs, respectively. Microinjection of fentanyl (0.4-10 nM) into the pontine micturition center (PMC) increased the bladder capacity by 4-46% (mean 18%) in cats. Naloxone injected into the… CONTINUE READING

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