Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo.

@article{Aimone1989OpioidMO,
  title={Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo.},
  author={L D Aimone and Tony L. Yaksh},
  journal={Peptides},
  year={1989},
  volume={10 6},
  pages={1127-31}
}
Capsaicin has been shown to evoke the release of substance P (SP) from small diameter primary afferent fibers. Using an in vivo perfusion of the rat spinal cord, this study examined the pharmacology of opioid receptor systems which modulate the capsaicin-evoked release of SP. The addition of capsaicin (200 microM) to the perfusate raised SP-like immunoreactivity (SP-LI) from resting levels of 31 +/- 5 to 74 +/- 14 pg/ml or an increase of 139% above the baseline. Using high pressure liquid… CONTINUE READING

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