Opioid modulation of Fos protein expression and olfactory circuitry plays a pivotal role in what neonates remember.

@article{Roth2006OpioidMO,
  title={Opioid modulation of Fos protein expression and olfactory circuitry plays a pivotal role in what neonates remember.},
  author={Tania L Roth and St{\'e}phanie Moriceau and Regina M Sullivan},
  journal={Learning & memory},
  year={2006},
  volume={13 5},
  pages={590-8}
}
Paradoxically, fear conditioning (odor-0.5 mA shock) yields a learned odor preference in the neonate, presumably due to a unique learning and memory circuit that does not include apparent amygdala participation. Post-training opioid antagonism with naltrexone (NTX) blocks consolidation of this odor preference and instead yields memory of a learned odor aversion. Here we characterize the neural circuitry underlying this switch during memory consolidation. Experiment 1 assessed post-training… CONTINUE READING