Opioid-modulating peptides: mechanisms of action.

  title={Opioid-modulating peptides: mechanisms of action.},
  author={Catherine Mollereau and Michel Roumy and Jean-marie Zajac},
  journal={Current topics in medicinal chemistry},
  volume={5 3},
Opioids are involved in the physiological control of numerous functions of the central nervous system, particularly nociception. It appears that some endogenous neuropeptides, called anti-opioids, participate in an homeostatic system tending to reduce the effects of opioids. Neuropeptide FF (NPFF) and cholecystokinin (CCK) possess these properties and, paradoxically, the opioid peptides nociceptin and dynorphin display some anti-opioid activity. All these peptides exhibit complex properties as… CONTINUE READING

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