Opioid-mediated facilitation of long-term depression in rat hippocampus.

  title={Opioid-mediated facilitation of long-term depression in rat hippocampus.},
  author={J. Joseph Wagner and Lida R Etemad and Angela M Thompson},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={296 3},
Previous studies have demonstrated that opioid substances are often inhibitors of the gamma-aminobutyric acid (GABA) transmitter system in the hippocampal formation, and that GABA-mediated inhibition is a potent modulator of synaptic plasticity. Field excitatory postsynaptic potentials were recorded from the CA1 region of rat hippocampal slices in response to stimulation of the Schaffer collateral fibers to monitor the effects of acute opioid exposure on the induction of long-term depression… CONTINUE READING
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