Opioid mechanisms are involved in the disruption of arcaine-induced amnesia by context pre-exposure

@article{Rosa2012OpioidMA,
  title={Opioid mechanisms are involved in the disruption of arcaine-induced amnesia by context pre-exposure},
  author={Michelle Melgarejo da Rosa and Carlos Fernando Mello and Keli Camera and Ana Paula Chiapinotto Ceretta and Daniela Aymone Ribeiro and Cristiane Signor and Maribel A Rubin},
  journal={Neurobiology of Learning and Memory},
  year={2012},
  volume={97},
  pages={294-300}
}
Previous exposure to the training context disrupts glutamatergic N-methyl-d-aspartate receptor (NMDAr) antagonist-induced amnesia, indicating that novelty is necessary for such an amnestic effect. While there are reports that novelty-related release of opioids cause amnesia, no study has addressed whether the amnestic effect of NMDAr antagonists involve opioid mechanisms. In this study we investigated whether pharmacological manipulation of the opioid system immediately after context pre… CONTINUE READING
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