Opioid inhibition of reflex urinary bladder contractions: dissociation of supraspinal and spinal mechanisms.

@article{Dray1985OpioidIO,
  title={Opioid inhibition of reflex urinary bladder contractions: dissociation of supraspinal and spinal mechanisms.},
  author={Andy Dray and L J Nunan},
  journal={Brain research},
  year={1985},
  volume={337 1},
  pages={142-5}
}
The supraspinal and spinal mechanisms of morphine induced inhibition of reflex urinary bladder contractions were studied in the urethane anesthetized rat. The inhibition of bladder contractions by intracerebroventricular (i.c.v.) morphine was abolished by intrathecal (i.t.) naloxone. In addition systemic reserpine (3.5-5.0 mg/kg, i.p.) abolished the inhibitory effect of both systemic morphine and i.c.v. morphine but not that of i.t. morphine. These data support the involvement of separate… CONTINUE READING

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