Opioid-induced respiratory depression is associated with increased tidal volume variability.

@article{Bouillon2003OpioidinducedRD,
  title={Opioid-induced respiratory depression is associated with increased tidal volume variability.},
  author={Thomas W. Bouillon and Joergen Bruhn and Heiko Roepcke and Andreas Hoeft},
  journal={European journal of anaesthesiology},
  year={2003},
  volume={20 2},
  pages={127-33}
}
BACKGROUND AND OBJECTIVE mu-agonistic opioids cause concentration-dependent hypoventilation and increased irregularity of breathing. The aim was to quantify opioid-induced irregularity of breathing and to investigate its time-course during and after an opioid infusion, and its ability to predict the severity of respiratory depression. METHODS Twenty-three patients breathing spontaneously via a continuous positive airway pressure (CPAP) mask received an intravenous (i.v.) infusion of… CONTINUE READING

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