Opioid-induced hyperalgesia and tolerance.

@article{Bekhit2010OpioidinducedHA,
  title={Opioid-induced hyperalgesia and tolerance.},
  author={Mary Hanna Bekhit},
  journal={American journal of therapeutics},
  year={2010},
  volume={17 5},
  pages={498-510}
}
We have all encountered the following postanesthesia care unit dilemma a myriad of times. As the attending covering the postanesthesia care unit, the anesthesiologist will be confronted not infrequently with the following clinical scenario: "He needed 500 μg fentanyl in the operating room for a toe amputation and has received 20 mg morphine, and he's still complaining of severe pain…. Do you think he may need more morphine?" Opiates do prevail as first-line therapy for moderate to severe… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Opioid Induced Hyperalgesia

M Mudely
2011
View 4 Excerpts
Highly Influenced

Epigenetics in the perioperative period.

British journal of pharmacology • 2015
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Opioid tolerance and hyperalgesia.

The Medical clinics of North America • 2007
View 5 Excerpts
Highly Influenced

evidence for a nociceptive facilitating function of the rostral ventromedial medulla

H Kaplan, Fields HL. Hyperalgesia during acute opioid abstinence
J Neurosci. 1991;11: 1433–1439. www.americantherapeutics.com American Journal of Therapeutics • 2010

Pathophysiology of pain.

The Medical clinics of North America • 2007
View 1 Excerpt

Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry • 2004

Similar Papers

Loading similar papers…