Opioid-induced hyperalgesia and tolerance.

  title={Opioid-induced hyperalgesia and tolerance.},
  author={Mary Hanna Bekhit},
  journal={American journal of therapeutics},
  volume={17 5},
We have all encountered the following postanesthesia care unit dilemma a myriad of times. As the attending covering the postanesthesia care unit, the anesthesiologist will be confronted not infrequently with the following clinical scenario: "He needed 500 μg fentanyl in the operating room for a toe amputation and has received 20 mg morphine, and he's still complaining of severe pain…. Do you think he may need more morphine?" Opiates do prevail as first-line therapy for moderate to severe… CONTINUE READING


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