Opioid-induced hyperalgesia: clinically relevant or extraneous research phenomenon?


Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or aggravate preexisting pain, may occur… (More)
DOI: 10.1007/s11916-010-0171-1


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