Opioid-induced hyperalgesia: clinically relevant or extraneous research phenomenon?

  title={Opioid-induced hyperalgesia: clinically relevant or extraneous research phenomenon?},
  author={David Andrew Tompkins and Claudia M. Campbell},
  journal={Current pain and headache reports},
  volume={15 2},
Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or aggravate preexisting pain, may occur. Over the past several decades, an increasing number of laboratory and clinical reports have suggested lowered pain thresholds and heightened… CONTINUE READING
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Hyperalgesia in pain patients at elevated risk for opioid misuse

  • RR Edwards, A Wasan, R. Jamison
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